I have told you these things, so that in Me you may have [perfect] peace and confidence. In the world you have tribulation and trials and distress and frustration; but be of good cheer [take courage; be confident, certain, undaunted]!  For I have overcome the world. [I have deprived it of power to harm you and have conquered it for you.
(John 16:33, Amplified Bible)

When you pray in the Spirit you are dwelling and abiding in the very presence of the throne room of Heaven.  Your prayers are being heard and the utterances are sent from the Holy Spirit of God Almighty.  “He who dwells in the secret place of the Most High shall abide under the shadow of the Almighty” (Psalm 91:1).  There is a tremendous power in your prayer that releases the very power of God Almighty on this Earth.  The devil will use every trick and distraction including the cares of this life with persecution and loved ones to discourage you from entering in to praying in the Spirit. Jesus says in Matthew 18:18-20:

Again I say to you that if two of you agree on earth concerning anything that they ask, it will be done for them by My Father in heaven.  For where two or three are gathered together in My name, I am there in the midst of them.

The devil will always cause division and strife to keep us from the unity of entering into the very power and presence of God.  The key to praying in the Spirit is to focus on the Lord Jesus and not on the circumstances.  Your victory and power comes from God Almighty and the Lord Jesus Christ.  When you focus on Jesus your faith will soar and you will enter into the secret place of abiding with the Most High.

But you, when you pray, go into your room, and when you have shut your door, pray to your Father who is in the secret place; and your Father who sees in secret will reward you openly.
(Matthew 6:6)